Retinal Vein Occlusion

Overview of branch retinal vein occlusion and central retinal vein occlusion.

What is a Retinal Vein Occlusion?

Arteries bring blood to the eye and veins bring blood back to the heart. While arteries have tough walls which usually become harder with age, veins have thin walls which remain pliant and soft throughout life. Because of the anatomy of the eye, the retinal veins are prone to occlusion. There are two main locations where retinal veins are occluded. One is at the crossing of a retinal arteriole and branch retinal vein. An occlusion at a crossing of a branch retinal arteriole and branch retinal vein causes a branch retinal vein occlusion. The second is at the main trunk of the retinal vein where it leaves the eye through the optic nerve. An occlusion at the main trunk of the retinal vein causes a central retinal vein occlusion. The picture shows a photo with dilated veins and retinal hemorrhages from a fresh central retinal vein occlusion.

What is a Branch Retinal Vein Occlusion?

A branch retinal vein occlusion occurs when, because of hardening of the arteries, a branch retinal artery compresses a branch retinal vein causing blockage of the vein and decreased circulation in the distribution of that branch retinal vein. (see image) [note: the branch arteries are really arteriols and the branch veins are really veinules] There are several possible treatments for branch retinal vein occlusion including intravitreal injections, laser, and even surgery. Patients with BRVO lose vision for several reasons: poor circulation, hemorrhage and macular edema (swelling). There is no treatment, at the moment, to increase circulation or to remove hemorrhage. The macular edema, however, does respond well to intravitreal injections with Lucentis, Avastin, or steroids.

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What is a Central Retinal Vein Occlusion?

The inner layers of the retina receive their blood supply from the central retinal artery. The blood returns to the heart through the central retinal vein. Both vessels enter the eye through a small opening in the middle of the optic nerve. Either because this opening shrinks or because the artery hardens or because of circulations problems, the central retinal vein can become partially or completely occluded. When a patient develops a central retinal vein occlusion (CRVO), they lose some or most of their central vision. The retinal veins dilate and their are retinal hemorrhages. Patients often develop swelling of the central retina-cystoid macular edema--causing some of the vision loss. Without treatments, 25% of eyes improve, 50% stabilize, and 25% worsen. Monthly examinations of pateints with CRVO for less than six months are very important. Some patients with CRVO and very bad circulation, develop a severe type of glaucoma. In this situation, the eye becomes red and painful and without treatment, total visual loss can occur rapidly. If an examining doctor sees early signs that this complication may occur, then laser treatment can sometimes protect the eye. Once the pressure rise occurs, surgery can be helpful.

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Retinal Vein Occlusion NEWS

Below are current articles from a Google News Feed on Retinal Vein Occlusion


No difference found in stroke type with or without anti-VEGFs
Healio
A total of 690 patients in the study group were identified as having received one or more intravitreal anti-VEGF injections for age-related macular degeneration, diabetic macular edema, proliferative diabetic retinopathy or retinal vein occlusion, and ...


Retinal Vein Occlusion – Market Outlook, H1 2017 Mentioning Key Vendors Formycon AG, Lupin Ltd, Mabion SA
Medgadget (blog)
HTF Market Intelligence released a new research report of 74 pages on title 'Retinal Vein Occlusion – Pipeline Review, H1 2017' with detailed analysis, forecast and strategies. The study covers key regions and important players such as Formycon AG ...


ModernMedicine

Laser retains limited role for management of RVO-related ME
ModernMedicine
In the current era where pharmacologic therapy is the preferred treatment for macular edema secondary to retinal vein occlusion (RVO), there is still a role for laser, according to Francesco Bandello, MD. “Laser photocoagulation–especially subthreshold ...


Widening use of dexamethasone implant for the treatment of macular edema
Dove Medical Press
Abstract: Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis.


Healio

Vascular Density of Retinal Capillary Plexuses in Different Subtypes of Macular Hole
Healio
Exclusion criteria for the study eye were a concurrent ocular disease other than macular hole involving the posterior segment (eg, uveitis, retinal vein occlusion, glaucoma, optic neuropathy), any previous posterior segment surgical or laser treatment ...


Triamcinolone 'Slurry' Comparable to Other Steroids for DME
MedPage Today
Over 60% of patients with cystoid macular edema had treatment due to diabetic retinopathy, while 15% had central retinal vein occlusion, or a blockage of the main vein of the retina, and 11% had uveitis, or an inflammation of the middle layer of the eye.


Retinal Vein Occlusion - Pipeline Review, H1 2017 Market Report; Launched via MarketResearchReports.com
Digital Journal
Retinal vein occlusion is a blockage in one of the veins returning blood flow from the retina. The retina is where images are converted to nerve signals. The primary symptom of retinal vein occlusion is a sudden painless change in vision. Predisposing ...


Ozurdex implant tolerated well, with IOP spikes transient and treatable
Healio
They received 1,000 injections for macular edema secondary to retinal vein occlusion, diabetic macular edema, postsurgical macular edema, uveitis and other etiologies. Pre-existing ocular hypertension or glaucoma was present in 14% of eyes. Re ...


Medscape

Should We WAVE Goodbye to Laser?
Medscape
There were no significant differences between the monotherapy and combination therapy groups in terms of mean gains in best corrected visual acuity or central retinal thickness after 1 year. Treatment burden was similar between the monotherapy and ...


No Increase in Stroke with Anti-VEGF Tx for Eye Disorders
MedPage Today
From 2004 to 2013, all patients who received anti-VEGF therapy for age-related macular degeneration, diabetic macular edema, proliferative diabetic retinopathy, and retinal vein occlusion were matched to several cohorts of age- and sex-matched controls ...

and more »

Nepafenac reduces risk for macular edema after cataract surgery in select patients
Healio
In total, 4.2% of patients in the cohort with preoperative risk factors, such as contralateral PCME, diabetic retinopathy, retinal vein occlusion, macular hole or epiretinal membrane, developed PCME compared with 2% of patients without preoperative ...


BZ Weekly

Clearside Biomedical's (CLSD) CEO Daniel White on Q2 2017 Results - Earnings Call Transcript
Seeking Alpha
... by leveraging the exclusive access to and proprietary technology for suprachoroidal injection of drugs to access the retina and choroid, we believe the clinicians can more effectively treat sight threatening diseases like uveitis, Retinal Vein ...
Clearside Biomedical, Inc. Announces Second Quarter 2017 Financial Results and Provides Corporate UpdateGlobeNewswire (press release)
Clearside Biomedical, Inc. Announces Changes to its Board of DirectorsNasdaq
Clearside Biomedical, (CLSD) Recommendation Raised to Buy By Research Firm ZacksInsider Tradings
SEC.gov
all 110 news articles »

BioPharma-Reporter.com

Novartis preps production platform for alternative to Lucentis
BioPharma-Reporter.com
And last week during its Q2 results presentation head of Global Drug Development Vas Narasimhan said Novartis was set to move forward on studies in other indications – including diabetic macular edema (DME) and retinal vein occlusion (RVO) – and to ...


Reports Healthcare

What is an Eye Stroke? Causes, Symptoms and Treatment
Reports Healthcare
Just like the heart and brain, a human eye is also susceptible to strokes. An eye stroke is a condition whereby the retina's blood supply is cut off and if medical attention is not given at the time, it may lead to troubled vision.


DailyNewsKs

Retinal Vein Occlusion Market 2017 Trends, Top Manufactures, Market Demands, Industry Growth Analysis & Forecast ...
DailyNewsKs
Retinal Vein Occlusion Market Pipeline Review, H1 2017, latest research study provides in depth analysis on Cellular Tumor Antigen P53 (Tumor Suppressor P53 or Antigen NY-CO-13) targeted pipeline therapeutics. Retinal Vein Occlusion therapeutics ...

and more »

When Robots Become Specialists
Medical Device and Diagnostics Industry
In January, eye surgeons at University Hospitals Leuven, in Belgium, became the first to use a procedure-specific robot to perform retinal vein occlusion surgery. Treatment for this condition, which can cause blindness, is currently limited to ...


Clearside Biomedical, Inc. to Report Second Quarter 2017 Financial Results on August 9, 2017 – Conference Call to ...
GlobeNewswire (press release)
This offers potentially meaningful treatment benefit to patients suffering from sight threatening diseases like uveitis, retinal vein occlusion, diabetic macular edema and wet age-related macular degeneration. To learn more about how Clearside is ...

and more »

National Institutes of Health (press release)

Avastin as effective as Eylea for treating central retinal vein occlusion
National Institutes of Health (press release)
Monthly eye injections of Avastin (bevacizumab) are as effective as the more expensive drug Eylea (aflibercept) for the treatment of central retinal vein occlusion (CRVO), according to a clinical trial funded by the National Eye Institute (NEI), part ...

and more »

Notal Vision Welcomes Roni Amiel as Chief Information Officer
Markets Insider
Notal's next home-based telemonitoring application, the Notal Home OCT, may have the potential to expand the patient groups who benefit from ophthalmic telemedicine beyond wet AMD, to include diabetic macular edema, branch retinal vein occlusion, ...

and more »

DRIL Predicts Future Visual Impairment in VO-ME Patients
MedPage Today
Greater extent of disorganization of the retinal layers (DRIL) among patients with macular edema secondary to vein occlusion, as seen on optical coherence tomography, was significantly correlated with worse best-corrected visual acuity scores, reported ...


Bevacizumab On Par With Aflibercept in Retinal Vein Occlusion
MedPage Today
Bevacizumab (Avastin) had similar visual acuity outcomes to aflibercept (Eylea) in patients who had macular edema from central retinal vein or hemiretinal vein occlusion, researchers found. In the SCORE2 trial, mean visual acuity letter score (VALS) ...


News-Medical.net

Central Retinal Vein Occlusion (CRVO)
News-Medical.net
Central retinal vein occlusion (CRVO) is the most common disease of the retinal vessels. It refers to a blockage of the vein draining the retinal tissue at the back of the eye. Occurring mostly in the elderly or middle-aged, it causes a subacute loss ...
US, UK trials underway to compare treatments for CRVOHealio

all 3 news articles »

The Pharmaceutical Journal

Bevacizumab as effective as aflibercept for central retinal vein occlusion
The Pharmaceutical Journal
Off-label drug is as effective as standard treatment for macular oedema, according to randomised controlled trial. Retinal image showing macular oedema. Source: Shutterstock.com. Researchers have demonstrated the efficacy of bevacizumab for treating ...


Optical Coherence Tomography Angiography Equipment Market to Develop Rapidly by 2024
Digital Journal
By application angiography equipment market is segmented as: Diabetic Retinopathy, Retinal Vein Occlusion, Age related Macular Degeneration, Ocular Histoplasmosis, Retinal breaks and detachment, Central Serous Chorioretinopathy, Ocular Tumors.


Digital Journal

Retinal disease pharmaceutical sales will reach $11.98bn in 2017
Digital Journal
Companies seek to improve upon the standard of care (SOC) treatment for wAMD, whilst developing new therapies for dry AMD and other retinal diseases such as diabetic retinopathy (DR) and retinal vein occlusion (RVO). The retinal disease overall market ...


Science Daily

Surgical eye robot performs precision-injection in patient with retinal vein occlusion
Science Daily
In case of retinal vein occlusion (RVO) there is a blood clot in one of the retinal veins. This leads to reduced eyesight or even blindness in the eye affected. At the moment, treatment consists of monthly injections in the eye that only reduce the ...
Surgeons Perform a Procedure with This Surgical Robot, Making Highly Precise Eye Injection PossibleWccftech

all 3 news articles »

Clearside Biomedical, Inc. (NASDAQ:CLSD) Rating Lowered to Hold at Zacks Investment Research
BNB Daily (blog)
Its products include CLS-1001 for the treatment of macular edema associated with non-infectious uveitis; CLS-1003 for the treatment of macular edema associated with retinal vein occlusion; and CLS-1002 program for the treatment of wet age-related ...

and more »

Macular Edema – Pharmaceutical and Healthcare Disease Pipeline Review, H1 2017 Including Key Players Mabion ...
Medgadget (blog)
It is frequently associated with diabetes, where damaged blood vessels in the retina begin to leak fluids, including small amounts of blood, into the retina. Other causes include retinal vein occlusion, side effects of certain medications and certain ...


Surgical robot successfully removes blood clot in patient with retinal vein occlusion
Healio
Blockage from a blood clot causing retinal vein occlusion in a patient was for the first time removed with the help of a surgical robot at the University Hospitals Leuven, Belgium. Operated by Peter Stalmans, MD, PhD, the robot injected ocriplasmin ...


Assessment of ischemia in acute central retinal vein occlusion from inner retinal reflectivity on spectral domain ...
Dove Medical Press
Purpose: To determine the relationship between different spectral domain optical coherence tomography (SD-OCT) signs of retinal ischemia in acute central retinal vein occlusion (CRVO) and whether they predict anterior segment neovascularization (ASNV).

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