Dry Age Related Macular Degeneration

Overview of mild, moderate and severe dry AMD including drusen and geographic atrophy.

What are Drusen?

The hallmark of dry AMD is macular drusen (see photo). Drusen are made up of lipids, a type of fatty protein. They may be the result of a failure of the eye to dispose of waste products that are produced when the photoreceptors of the eye drop off older parts of the cell. There are several types of drusen with different levels of risk. Drusen can be small, hard and scattered far apart from each other. They are round and distinct. This type may not create vision problems for a long time and may not even be an indication of macular degeneration. Some drusen can become larger, softer and closer together. Their edges are less distinct. When they get to that stage, there is a greater risk for developing wet macular degeneration and more severe vision loss. They can also disrupt the layers of the retina and may lead to retinal pigment epithelium detachment (PED). Your doctor can see these drusen during a dilated eye exam, even if you are not aware of a vision change. That is one reason why regular eye exams are so important. If you have the larger, soft drusen, your doctor will probably want you to come into the office for check-ups more often. If they do lead to wet macular degeneration, early treatment is essential.

What is Geographic Atrophy?

Geographic atrophy occurs when the photoreceptors (seeing part of the retina) no longer works and the patient develops a blind spot or spot of poor vision in the macula (see photo). Geographic atrophy (GA) is considered the late stage of the dry form of Age-related Macular Degeneration (AMD). It only occurs in about 10 percent of dry AMD patients. GA is usually a sharply delineated round or oval area of hypopigmentation, or apparent absence of the retinal pigment epithelium (RPE), in which choroidal vessels are more visible than in surrounding areas The most common sequence of events leading to GA is the progression of a large drusen to hyperpigmentation, followed by regression of the drusen, hypopigmentation and ultimately RPE cell death, with development of an atrophic area of retina and underlying choriocapillaris, sometimes preceded by the appearance of refractile deposits. This usually takes more than 5 years. Less frequently, GA can follow a drusenoid RPE detachment, regression of a CNV membrane or a RPE rupture. As other forms of late AMD, GA tends to be bilateral (over 50% of cases) and there is high symmetry between eyes for total atrophic area, presence of peripapillary atrophy and enlargement rate. GA often first develops surrounding the fovea, sparing the central area.

What is Progressive Geographic Atrophy?

Geographic atrophy can progress and lead to vision loss. When people with dry AMD lose vision, it is almost always from geographic atrophy. The animated image with this text shows growing geographic atrophy over 3 years in an 86 year old patient. This person is fortunate to have good vision because the dark areas of geographic atrophy are not yet affecting the central vision. Given the progression, the central vision will likely be affected within about 10 years. The images are fundus autofluorescent images that are useful for following geographic atrophy because the atrophy shows up as well delineated dark spots.

What is Pattern Dystrophy?

Pattern dystrophy is a type of dry age-related macular degeneration that involves mostly the very center of the macula. There are several types of pattern dystrophy. The image with this text is of a patient with adult vitelliform macular dystrophy. The image shows the buildup of abnormal deposits under the retina in the center of the macula. Unlike typical dry macular degeneration where the buildup of material is below the retinal pigment epithelium, in pattern dystrophy, the buildup of material is above the pigment epithelium and directly beneath the retina (see asterisks on image). Pattern dysrophy is autosomal dominant, usually presents at a younger age than typical dry AMD, and usually does not progress to wet AMD.

Pattern Dystrophy

What about Diet?

Patients who consume fruits and vegetables have the lowest rates of macular degeneration development. Lutein, a carotenoid pigment found exclusively in fruit and vegetables, serves as the primary protector of the eye. Lutein accumulates in the macula and likely blocks the damage caused by sunlight, one proposed cause of AMD. Fruits and vegetables are also high in antioxidant vitamins such as Beta- carotene, Vitamin E, and Vitamin C. Green leafy vegetables and other colorful foods like kiwi, squash, red grapes, and corn are good sources of Lutein. Other dietary habits have been shown to increase the risk of AMD. Individuals with a higher percentage of vegetable, monounsaturated, and polyunsaturated fats in their diet have higher rates of Wet AMD development. Diets rich in Omega 3 fatty acids reduce the risk of vision loss. These are found naturally in cold-water fish such as salmon and tuna, and in flaxseeds and flaxseed oil. Two servings of fish per week are adequate.

What about Vitamins?

The Age-Related Eye Disease Study 2 showed that among people at high risk for developing late-stage, or wet, macular degeneration (such as those who have large amounts of drusen or who have significant vision loss in at least one eye), taking a dietary supplement of vitamin C, vitamin E, lutein and zeaxanthin, along with zinc, lowered the risk of macular degeneration progressing to advanced stages by at least 25 percent. The supplements did not appear to provide a benefit for people with minimal macular degeneration or people without evidence of the disease during the course of the study. These vitamins contain a mixture of Vitamins C and E, Lutein, Zeaxanthin, Zing and Copper. Another large study in women showed a benefit from taking folic acid and vitamins B6 and B12. It is very important to remember that vitamin supplements are not a cure for macular degeneration, nor will they give you back vision that you may have already lost from the disease. However, these supplements do play a key role in helping some people at high risk for developing advanced (wet) AMD to maintain their vision, or slow down the progression of the disease.

What about Amsler Grid?

One of the first signs of macular degeneration can be wavy, broken or distorted lines OR a blurred or missing area of vision. The Amsler Grid can help you spot these early. Early detection of wet AMD is critical because laser treatment, when indicated, is most successful when performed before damage occurs. Since dry AMD can lead to development of wet AMD, most patients should use the Amsler Grid. Check with your eye doctor to find out how often you should use this test. Wear your reading glasses, if you normally use them and sit about 14 inches away from the screen. Check one eye at a time. Cover the eye you are not testing. Focus on the dark dot in the center of the grid. While looking at this dot, you still should be aware of the lines of the grid. Notice if any of the lines are distorted or broken or if there are blurred areas.

Download Amsler Grid

Dry Macular Degeneration NEWS

Below are current articles from a Google News Feed on Dry Macular Degeneration

This RSS feed URL is deprecated, please update. New URLs can be found in the footers at https://news.google.com/news

Visual acuity loss associated with excessive "dry macula" in ...
Dove Medical Press
Visual acuity loss associated with excessive "dry macula" in exudative age-related macular degeneration Hidenori Takahashi,1�3 Yuji Inoue,1,2 Xue Tan,2,3 Satoru Inoda,1 Shinichi Sakamoto,1 Yusuke Arai,1 Yasuo Yanagi,4�6 Yujiro Fujino,2,3 Hidetoshi ...

and more »

Global Age-related Macular Degeneration Market 2017 – Recent Study Including Growth Factors, Applications ...
Newsient (blog)
Global Age-related Macular Degeneration (Thousands Units) and Revenue (Million USD) Market Split by Product Type such as Wet AMD , Dry AMD , . Furthermore, the research study is segmented by Application such as Drugstore , Hospital , Others & Other ...

and more »

Big Island Now

Age-Related Macular Degeneration: Leading Cause of Blindness in Seniors
Big Island Now
“AMD develops slowly over time with symptoms often going unnoticed until significant damage has already occurred,” said M.D., Medical Director of Hawaiian Eye Center Christopher Tortora. “It causes central vision to blur while peripheral vision is ...

and more »

satPRnews (press release)

February is Age-related Macular Degeneration Month
Healio
Age-related macular degeneration, characterized by the loss of central vision, affects 1.65 million individuals in the United States and is the leading cause of vision loss in people older than 65 years, according to Friends for Sight, a nonprofit ...
Global Macular Edema And Macular Degeneration Market 2016 by Key Regions, With Production, Consumption ...satPRnews (press release)

all 2 news articles »

PR Newswire

Back of the Eye Disorders Markets, 2030 - Focus on Novel Drugs and Delivery Technologies
Markets Insider
Further, there are no treatment approaches available for a number of ophthalmological indications, such as dry age related macular degeneration (dry AMD), retinitis pigmentosa (RP) and leber congenital amaurosis. In order to overcome these challenges ...
Back of the Eye Disorders Markets, 2030 - Focus on Novel Drugs ...PR Newswire (press release)

all 1 news articles »

Hollywood Gazette

Hollywood Ophthalmologist Shares Six Tips to Prevent Macular Degeneration
Hollywood Gazette
The disease reduces the quality of central vision, ranging from a mild loss to a devastating impairment in vision. That is the bad news. Here is the good news. As a Bascom Palmer Eye Institute Fellowship Trained Ophthalmologist with more than 30 years ...
What is age-related macular degeneration and why should older Canadians care?Globalnews.ca

all 5 news articles »

Post Analyst

Catalyst Biosciences (NASDAQ:CBIO) Given a $49.00 Price Target at B. Riley
StockNewsTimes
Catalyst Biosciences logo Catalyst Biosciences (NASDAQ:CBIO) received a $49.00 price target from equities researchers at B. Riley in a research note issued on Friday, February 9th, Marketbeat reports. The brokerage currently has a “buy” rating on the ...
Catalyst Biosciences (NASDAQ:CBIO) Upgraded to “Sell” at ValuEngineThe Ledger Gazette

all 5 news articles »

MD Magazine

Low Luminance Questionnaire Linked to Functional Measures of AMD
MD Magazine
“It is important to determine accurate and patient-centered ways of assessing visual impairment in early and intermediate dry AMD,” lead author Atalie C. Thompson, MD, MPH, of the Duke University Department of Ophthalmology, Durham, North Carolina ...


University of Utah Health Care

February is AMD Awareness Month
University of Utah Health Care
AMD itself doesn't lead to complete blindness. However, the loss of central vision can be devastating in terms of the initial loss of independence. (Fortunately, patient support groups and low-vision aids are widely available.) There are two types of ...

and more »

Treehugger

Frying in olive oil infuses vegetables with extra nutrients
Treehugger
Say goodbye to insipid boiled veggies; frying can actually improve their nutritional profile, study finds. Here is a piece of happy news for you on a Tuesday morning. There is no need to compromise flavor for health! A new study out of the University ...


TAPinto.net

AMD Awareness Raises Questions
TAPinto.net
A: AMD stands for age-related macular degeneration, a disease that breaks down the macula - the light-sensitive portion of the retina that allows you to see fine detail. It blurs the “straight-ahead” vision required for activities such as reading or ...

and more »

TCPalm

Eye Institute holding ophthalmology seminars
TCPalm
Macular Degeneration is the leading cause of severe and irreversible vision loss. Proven FDA treatments can now dramatically improve sight and prevent further debilitation. Dr. Baudo explains the difference between Wet & Dry Macular Degeneration ...


StockNewsTimes

Zacks: Catalyst Biosciences Inc (CBIO) Receives Average Recommendation of “Strong Buy” from Analysts
StockNewsTimes
Catalyst Biosciences logo Catalyst Biosciences Inc (NASDAQ:CBIO) has received an average broker rating score of 1.00 (Strong Buy) from the three brokers that provide coverage for the company, Zacks Investment Research reports. Three investment analysts ...
Catalyst Biosciences, Inc. (CBIO) Analysts See $-1.79 EPSReurope
Catalyst Biosciences (CBIO) Given a $49.00 Price Target by B. Riley AnalystsDispatch Tribunal
Financial Newsletter - ZacksZacks

all 26 news articles »

Business Wire (press release)

Pixium Vision Completes World's First Successful Activation in Human of PRIMA Bionic Vision System
Business Wire (press release)
Pixium Vision (Paris:PIX) (FR0011950641 - PIX), a company developing innovative bionic vision systems to enable patients who have lost their sight to lead more independent lives, announces today the world's first successful human implantation and ...

and more »

East Anglian Daily Times

Blindness rates cut in Suffolk
East Anglian Daily Times
According to the NHS, AMD affects more than 600,000 people in the UK and is the leading cause of vision loss. By 2020, it's predicted almost 700,000 people will have late-stage AMD. For reasons that are unclear, AMD tends to be more common in women ...


Pixium Vision Announces Its 2017 Annual Results and Provides Business Update
Business Wire (press release)
The board of directors of Pixium Vision, chaired by Bernard Gilly, approved the annual results at a meeting on February 7, 2018. "Key achievements for Pixium Vision include the approval in France and in the United States of the first in human clinical ...


Jamestown Sun

Celebrate Valentine's Day with healthy strawberries
Jamestown Sun
They also help to reduce the presence of free radicals in our body that can cause dry eyes, macular degeneration and increased susceptibility to infections. A one-cup serving of strawberries has about 150 percent of our daily requirement for vitamin C ...

and more »

News-Medical.net

Pixium Vision announces successful implantation and activation of PRIMA Bionic Vision System
News-Medical.net
Pixium Vision (FR0011950641 - PIX), a company developing innovative bionic vision systems to enable patients who have lost their sight to lead more independent lives, announces today the world's first successful human implantation and activation of ...


MoneyMakingArticles

$-0.06 EPS Expected for BioTime, Inc. (BTX); Dorchester Minerals LP (DMLP) Sellers Decreased By 7.72% Their Shorts
MoneyMakingArticles
The Company's product candidates include Renevia, a facial aesthetics product that is in pivotal clinical trial for the treatment of HIV related facial lipoatrophy; OpRegen, which is in Phase I/IIa clinical trial for the treatment of the dry form of ...
BioTime, Inc. (BTX) Analysts See $-0.06 EPS - The BZ WeeklyBZ Weekly
Analysts See $-0.06 EPS for BioTime, Inc. (BTX) - Frisco FastballFrisco Fastball

all 6 news articles »

Global Ophthalmic Surgical Technologies Market Anticipated to Drive Demand due to Growing Prevalence of Eye ...
First Reporter
Eye care services include exams, treatment for dry eye, glaucoma, cataracts, diabetes, and macular degeneration. Ophthalmic surgery is a medical procedure involving an incision with instruments; performed to repair damage or arrest disease in eye ...


BZ Weekly

Ophthotech Corporation (OPHT) EPS Estimated At $-0.58
BZ Weekly
The Company's principal product candidate, Fovista, an anti-platelet derived growth factor, is in Phase III clinical development for use in combination with anti-vascular endothelial growth factor drugs for the treatment of wet age-related macular ...
$-0.58 EPS Expected for Ophthotech Corporation (OPHT)Frisco Fastball
A Reversal for Ophthotech Corporation (NASDAQ:OPHT) Is Near. The Stock Has Decrease in ShortsKL Daily
Ophthotech (OPHT) EPS Estimated At $-0.58; Shorts at NOKIAN TYRES PLC (NKRKF) Raised By 4.41%San Times
FlintDaily.com
all 34 news articles »

Medscape

Healthy Skepticism: Questioning a Study Linking Exercise to Increased Neovascular AMD Risk
Medscape
The study relied on self-reported frequency of vigorous physical activity, which was defined as "making you sweat." The incidence of neovascular AMD during the study period was the primary endpoint and was determined by diagnosis code and treatment ...


LumiThera, Inc. to Participate in the 2018 Glaucoma 360 in San Francisco
PR Newswire (press release)
We believe our presentation will provide researchers, physicians and investors with a snapshot of LumiThera's clinical development of a novel PBM treatment for dry age-related macular degeneration, and PBM's potential use in other degenerative eye ...

and more »

WFAA

Verify: Can an app replace a trip to the eye doctor?
WFAA
“20/20 doesn't mean that you don't have glaucoma, it doesn't mean you don't have cataracts, it doesn't mean that you don't have macular degeneration.” Hoelscher said what you really need every year is a comprehensive eye exam. “When we perform a ...

and more »

and Vision Restoration Programs to Be Presented at ARVO 2018
Business Wire (press release)
Renevia®, a cell delivery product, met its primary endpoint in an EU pivotal clinical trial for the treatment of facial lipoatrophy in HIV patients in 2017. Submission for approval of Renevia® in the EU is expected to be early 2018, with possible ...

and more »

UtahHerald.com

Ophthotech (OPHT) Analysts See $-0.58 EPS; Whale Rock Capital Management Has Raised Netflix (NFLX) Holding By ...
UtahHerald.com
The Company's principal product candidate, Fovista, an anti-platelet derived growth factor, is in Phase III clinical development for use in combination with anti-vascular endothelial growth factor drugs for the treatment of wet age-related macular ...
Willis Investment Counsel Has Upped Cisco Systems (CSCO) Position; 2 Bullish Analysts Covering Ophthotech (OPHT)Herald KS
Ophthotech (OPHT) Analysts See $-0.58 EPS; Bristow Group (BRS) Has 1.33 SentimentHuronReport

all 8 news articles »

Why AMD supplementation should not be casual
ModernMedicine
I disagree with an ongoing claim that supplementation with three retinal carotenoids is superior to supplementing with only two dietary carotenoids.1. For clinicians who prescribe supplements other than Age-Related Eye Disease Study (AREDS) II for high ...


Arizona Daily Star

Tucson health and wellness events for Feb. 12-18
Arizona Daily Star
2-5 p.m. Feb. 14. 594-5315. Healthy Living with Diabetes — La Vista at La Posada, 501 S. La Posada Circle. Interactive workshop for individuals with diabetes and their caregivers. Ages 18 and over. 1-3:30 p.m. Feb. 15. $20. 305-3410. pcoa.org. Sight ...


Ratings Alerts (blog)

Ophthalmic Devices Market Scope, Overview and Outlook 2018
Ratings Alerts (blog)
Ophthalmic devices are an aid in the diagnosis, monitoring, surgery and treatment of various eye related diseases such as cataract, age-related macular degeneration, glaucoma, diabetic retinopathy, retinal detachment or tear, eye infections, dry eye ...

and more »

Catalyst Biosciences (CBIO) Price Target Increased to $75.00 by Analysts at Chardan Capital
The Ledger Gazette
Catalyst Biosciences Inc logo Catalyst Biosciences (NASDAQ:CBIO) had its target price boosted by Chardan Capital from $10.00 to $75.00 in a research report released on Friday, February 9th, MarketBeat Ratings reports. Chardan Capital currently has a ...

and more »
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What about Resources?

Dr. Pautler's Blog
American Academy of Ophthalmology
MedlinePlus
National Institutes of Health
  • ARMD
    NIH's SeniorHealth website covers the topic of Age-Related Macular Degeneration
National Eye Institute
American Foundation for the Blind - Senior Site
  • Macular Degeneration
    Basic information about AMD and low vision; includes a self-test using an Amsler Grid
Journal of the American Medical Association (JAMA)
WebMD
LightHouse International
  • Macular Degeneration
    Provides a general overview of the basics of AMD, and a simulation showing a scene as it might be viewed by a person with AMD
Prevent Blindness America